A cholera outbreak threatens the town. The McGinnes Brothers clean up Durant’s mess after a deadly altercation with Senator Metcalf. The Swede, masquerading as Bishop Dutson, arrives at the Mormon fort.
Facing the noose for murder, Ruth’s life hinges on desperate efforts to save Sydney’s life. Ruth recalls memories of her father from childhood. Mickey’s cousin arrives to help fend off Campbell’s men – by any means necessary.
On the run evading certain death, an enigmatic old colleague of Bohannon’s stirs trouble when he suddenly shows up in Cheyenne. Brigham Young arrives at the Mormon compound to investigate the Swede. Mickey seeks revenge.
Hell on Wheel is reduced to ashes when the Swede enacts revenge with the help of the Sioux. Someone’s life comes to a tragic end as Durant’s fraudulent activities risk exposure. Ruth rejects Sean’s advances.
Cullen returns to the Mormon Fort only to discover it abandoned following a brutal smallpox epidemic. Desperate to find his lost family, Cullen wrestles with a difficult decision when he is poached by the Central Pacific Railroad.