Paranoia swarms as Sisko and Odo work to prevent a military power-grab at Starfleet Command, while the Defiant is believed to have been overtaken by Changelings.
Against the will of the Prophets, Sisko marries Kassidy Yates while Worf and Ezri are held captive on a Breen vessel. Dukat continues using Kai Winn to unleash his sinister plan.
With Grand Nagus Zek en route to DS9 to announce retirement, Quark is believed to be appointed his replacement. Meanwhile, an ambushed Kira, Damar, and Garak elude capture on Cardassia.
While on leave on Earth, Sisko uncovers a long-held secret after receiving visions of a mysterious woman. An "old" friend makes a stunning return and Kira clashes with a Romulan Senator.
While administrating a potential cure for Sarina, one of the fellow genetically-engineered individuals he previously assisted, Dr. Bashir develops deep romantic feelings for her.
Altered to appear Bajoran, Gul Dukat manipulates Kai Winn into studying how to release the Pah-wraiths, while the new Breen-Dominion alliance takes center-stage.
To prevent additional Dominion reinforcements, DS9 mines the wormhole’s entrance, escalating tensions between the Federation and Dominion… leading to a climatic ending.